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COTH

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Suggested by: Avital Cher

Description

COTH (CO-THreader) is a multiple-chain protein threading algorithm which is designed to identify and recombine protein complex structures from both tertiary and complex structure libraries. It first generates complex query-template alignments based on sequence profile-profile alignment assisted by the ab initio binding-site predictions from BSpred. The monomer structures from tertiary template library are then combined into the complex framework by structure superposition.

The output of the COTH server include:
-Top ten complex template alignments.
-COTH recombination models of tertiary template with quaternary framework.

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