COTH (CO-THreader) is a multiple-chain protein threading algorithm which is designed to identify and recombine protein complex structures from both tertiary and complex structure libraries. It first generates complex query-template alignments based on sequence profile-profile alignment assisted by the ab initio binding-site predictions from BSpred. The monomer structures from tertiary template library are then combined into the complex framework by structure superposition.
The output of the COTH server include:
-Top ten complex template alignments.
-COTH recombination models of tertiary template with quaternary framework.